A major unresolved challenge to curing HIV-1 is its presence in the nucleus of infected cells. This study reports on new ...
Progressive cardiomyopathy with intercalated disc disorganization in a rat model of Becker dystrophy
This new genome-edited rat model of Becker muscular dystrophy (BMD) develops progressive heart failure with reduced ejection ...
The Krebs cycle byproduct itaconate regulates immune cell function, however its role within tumor cells remains unclear. Here ...
In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et al (2024) identify PCPE-1 as a brown-adipose tissue-derived mediator of ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aurora-A is an essential cell-cycle kinase ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The precise organization of pre- and ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Evidence suggests mitochondrial homeostasis ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein copy numbers constrain systems-level ...
Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aneuploidy, while detrimental to untransformed ...
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