BMJ12h
Myelin oligodendrocyte glycoprotein-associated disorders are associated with HLA subtypes in a Chinese paediatric-onset cohort
Objective Myelin oligodendrocyte glycoprotein-associated disorders (MOGADs) are a rare new neurological autoimmune disease with unclear pathogenesis. Since a linkage of the disease to the human ...
BMJ5d
TDP-43 proteinopathies: a new wave of neurodegenerative diseases
Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For ...
BMJ5d
Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
Correspondence to Dr K F Pedersen, The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway; kenfrp{at}online.no Background: Apathy is a common ...
BMJ5d
Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy
Background Development of autonomic failure is associated with more rapid disease course and shorter survival in patients with Parkinson’s disease and multiple system atrophy. However, autonomic ...
BMJ5d
The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis
Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white ...
BMJ5d
Normal pressure hydrocephalus: long-term outcome after shunt surgery
Background/objective: Little is known about the long-term clinical course and management of patients with normal pressure hydrocephalus (NPH) treated by cerebrospinal fluid (CSF) shunting. Methods: We ...
BMJ1d
Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes
Objective The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson’s disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein ...
BMJ5d
Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition
Objective To explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we ...
BMJ5d
Cladribine: mechanisms and mysteries in multiple sclerosis
Correspondence to Dr Benjamin Meir Jacobs, Centre for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, London E1 2AT, UK; ben.meir.jacobs{at}gmail.com ...
BMJ5d
The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease
The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway Background: Neuropsychiatric symptoms are common in Parkinson’s disease (PD) and have important clinical ...
BMJ5d
Expanding the phenotype of MOG antibody-associated disease (MOGAD): half a century of epilepsy and relapsing optic neuritis
Correspondence to Dr Axel Petzold, UCLH NHNN, UCL ION, Queen Square, Moorfields Eye Hospital City Road Campus, London WC1E 6BT, UK; a.petzold{at}ucl.ac.uk The 69-year-old woman with relapsing ON ...
BMJ5d
Migraine and PPPD: how can we differentiate between these entities?
Background Migraine and Persistent Postural Perceptual Dizziness (PPPD) are two diagnostically challenging causes of episodic vertigo. We aim to describe and compare the Niigata PPPD Questionnaire ...