The 49ers will have a phenomenal chance to continue winning games if Brock Purdy does more of this.

SANTA CLARA, Calif. (AP) — The San Francisco 49ers placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season. The move comes after the Niners had previously voided $27 million guaranteed in his contract for next season for failing to participate in meetings and other team activities.

A recharged San Francisco 49ers squad returns from a late season break with renewed momentum as quarterback Brock Purdy guides a push toward an NFC West shake-up.

San Francisco 49ers quarterback Brock Purdy is officially out for Sunday's game against the Tampa Bay Buccaneers due to the toe injury that has caused him to miss multiple games already this season. Backup quarterback Mac Jones is listed as questionable ...

San Francisco 49ers star running back Christian McCaffrey was added to the team's injury report Saturday due to a back injury.

Part of what made going into the 2025 season an exciting one for the San Francisco 49ers was the young talent they have.

Los 49ers de San Francisco colocaron al receptor Brandon Aiyuk en la lista de reserva, lo que lo hace inelegible para regresar de una lesión de rodilla esta temporada.

The San Francisco 49ers are bringing up two players from the practice squad for their Week 15 battle with the Tennessee Titans.