Louisiana’s first-in-the-nation law listing the abortion medications mifepristone and misoprostol as “controlled dangerous substances” took effect Tuesday, triggering fears among health-care providers and pharmacists that routine care may be worsened for women in the state.

Two drugs used in pregnancy care are now under lock and key in Louisiana after a new law took effect Tuesday.

Starting Tuesday in Louisiana, mifepristone and misoprostol will be reclassified as controlled substances in the state, making it a crime punishable by up to five years in prison to possess the drugs without a prescription.