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WEB6 days ago · Physician seeks US PhD to tackle sickle cell disease in Nigeria. A Nigerian hematologist will pursue a PhD in health policy at the University of Tennessee Health Science Center to help advance her work on programs for sickle cell disease (SCD) in her home country. Aisha Galadanci Akilu, MD, helped implement a newborn screening program in …
Pfizer withdraws Oxbryta from global markets, cites safety concerns
WEB4 hours ago · Initially developed by Global Blood Therapeutics, now a Pfizer subsidiary, Oxbryta received conditional approval from the FDA in 2019 for SCD patients, ages 12 and older. The approval was extended to children as young as 4 in 2021. In 2022, the therapy was approved in the European Union, when given alone or in combination with the standard SCD treatment hydroxyurea, for patients ages 12 and older.
Vaso-Occlusive Crisis - Sickle Cell Disease News
WEBJan 4, 2022 · A vaso-occlusive crisis, or VOC, occurs when sickled red blood cells block blood flow to the point that tissues become deprived of oxygen. This in turn sets in motion an inflammatory response as the body tries to rectify the problem. The result is substantial pain, which can affect any part of the body, but most commonly occurs in the back ...
Gene Therapy – Sickle Cell Disease News
WEBFour trials (NCT02186418, NCT03282656, NCT02247843, NCT02140554) are testing the efficacy and safety of gene therapy to replace the mutated HBB gene with a healthy HBB gene.These Phase 2 trials are recruiting both children and adults in the United States and Jamaica. Three trials (NCT02193191, NCT02989701, NCT03226691) are investigating the use of Mozobil (plerixafor) in patients with sickle ...
Oxygen therapy for sickle cell disease
WEBAug 20, 2024 · Oxygen therapy, which involves having a person breathe in extra oxygen, is a medical intervention that may be used to help manage acute complications of sickle cell disease (SCD) associated with vaso-occlusion, or blood vessel blockage. It also has been proposed as a preventive or supportive measure for SCD patients in other situations, but ...
Sickle Cell 101: Addressing Common Questions About My Blood …
WEBSep 10, 2019 · Sickle cell is an inherited disorder that affects the blood’s ability to carry oxygen. The red blood cells in my body are shaped like a “C” instead of the typical “O.”. A consequence of having these sickle-shaped red blood cells is that they can stick together, which restricts the flow in my blood vessels. This causes severe pain ...
Stem cell transplant for sickle cell disease
WEBAug 21, 2024 · A stem cell transplant — also known as a bone marrow transplant, and more formally referred to as hematopoietic stem cell transplantation (HSCT) — is an invasive procedure that can be used to enable people with sickle cell disease (SCD) to produce healthy red blood cells. The bone marrow is home …
Red Blood Cell Biomarkers May Predict SCD Severity, Crisis Risk
WEBFeb 24, 2022 · by Steve Bryson, PhD February 24, 2022. Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. “Our latest research indicates that one of our clinically available red blood cell health tests called Flow Adhesion of Whole ...
Longer Life Expectancy Possible for Some Sickle Cell Patients
WEBby Alice Melão October 11, 2016. A published case study reports that patients with mildly symptomatic sickle cell disease (SCD) can exceed the U.S. median life expectancy of 47 years for patients with the disease if it is managed properly. The report published in Blood, the Journal of the American Society of Hematolog y, “ Case series of ...
What I’ve Learned About Protein and Sickle Cell Disease
WEBSep 8, 2021 · This is shortened to 8-25 days for those with sickle cell disease. This means that the bone marrow is constantly under pressure to churn out new red blood cells. This process needs plenty of energy, and since blood cells are made of protein, a person with sickle cell needs more protein. Protein is made up of building blocks called amino acids.